[hal-01111919] L'inscription en comptabilité d'opérations litigieuses n'empêche pas leur caractérisation en relations financières anormales

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[hal-01111918] Restez groupés...

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[hal-01111916] Sort des sommes déposées à la Caisse des dépôts en vue de la répartition des dividendes dans le cadre d'un plan en cas de liquidation judiciaire subséquente

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from HAL : Dernières publications http://ift.tt/1yoBhUT

[hal-01111915] Sanction des dirigeants: revirement sur la détermination de la date de cessation des paiements

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from HAL : Dernières publications http://ift.tt/1HDELwe

[hal-01111914] Plan de cession versus plan de continuation: la faveur discrète de la Cour de cassation envers la cession

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from HAL : Dernières publications http://ift.tt/1yoBffu

[hal-01111913] L'action en paiement du solde d'un compte courant d'associé n'est pas un droit propre

Note sous Cass. com. 23 sep. 2014, n° 12-29262



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[pasteur-01101526] Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

From a research program aimed at the design of new chemical entities followed by extensive screening on various models of infectious diseases, an original series of 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidines endowed with notable antiviral properties were found. Using a whole cell measles virus replication assay, we describe here some aspects of the iterative process that, from 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)pyrimidine, led to 2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-5-ethylpyrimidine and a 4000-fold improvement of antiviral activity with a subnanomolar level of inhibition. Moreover, recent precedents in the literature describing antiviral derivatives acting at the level of the de novo pyrimidine biosynthetic pathway led us to determine that the mode of action of this series is based on the inhibition of the cellular dihydroorotate dehydrogenase (DHODH), the fourth enzyme of this pathway. Biochemical studies with recombinant human DHODH led us to measure IC50 as low as 13 nM for the best example of this original series when using 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone (coenzyme Q1) as a surrogate for coenzyme Q10, the cofactor of this enzyme.



from HAL : Dernières publications http://ift.tt/1APndrM

[hal-01111916] Sort des sommes déposées à la Caisse des dépôts en vue de la répartition des dividendes dans le cadre d'un plan en cas de liquidation judiciaire subséquente

[...]



from HAL : Dernières publications http://ift.tt/1yoBhUT

[hal-01111915] Sanction des dirigeants: revirement sur la détermination de la date de cessation des paiements

[...]



from HAL : Dernières publications http://ift.tt/1HDELwe

[hal-01111914] Plan de cession versus plan de continuation: la faveur discrète de la Cour de cassation envers la cession

[...]



from HAL : Dernières publications http://ift.tt/1yoBffu

[hal-01111913] L'action en paiement du solde d'un compte courant d'associé n'est pas un droit propre

Note sous Cass. com. 23 sep. 2014, n° 12-29262



from HAL : Dernières publications http://ift.tt/1HDEJoc

[pasteur-01101526] Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)

From a research program aimed at the design of new chemical entities followed by extensive screening on various models of infectious diseases, an original series of 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidines endowed with notable antiviral properties were found. Using a whole cell measles virus replication assay, we describe here some aspects of the iterative process that, from 2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)pyrimidine, led to 2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-5-ethylpyrimidine and a 4000-fold improvement of antiviral activity with a subnanomolar level of inhibition. Moreover, recent precedents in the literature describing antiviral derivatives acting at the level of the de novo pyrimidine biosynthetic pathway led us to determine that the mode of action of this series is based on the inhibition of the cellular dihydroorotate dehydrogenase (DHODH), the fourth enzyme of this pathway. Biochemical studies with recombinant human DHODH led us to measure IC50 as low as 13 nM for the best example of this original series when using 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone (coenzyme Q1) as a surrogate for coenzyme Q10, the cofactor of this enzyme.



from HAL : Dernières publications http://ift.tt/1APndrM

[medihal-01110991] Le "Panier", terre d’asile

Le très touristique Panier, un des plus anciens quartiers de Marseille (2ème arrondissement), est aussi connu comme le premier quartier d’installation des migrants dans la ville. D’abord nommé le « village corse » de Marseille, cette tradition se poursuit aujourd’hui avec ses habitants d’origine maghrébine, vietnamienne, etc.



from HAL : Dernières publications http://ift.tt/1wEwXil

[medihal-01110996] La Bônoise

La Bône était le nom donné à la ville d’Annaba (Algérie) pendant la période coloniale. Aujourd’hui elle est aussi considérée comme la capitale des harraga (qui signifie « brûleurs » en arabe algérien). Ce terme désigne les « brûleurs de frontières » qui décident de quitter la rive sud de la Méditerranée pour rejoindre illégalement l’Europe.



from HAL : Dernières publications http://ift.tt/1wEwX1V

[medihal-01110991] Le "Panier", terre d’asile

Le très touristique Panier, un des plus anciens quartiers de Marseille (2ème arrondissement), est aussi connu comme le premier quartier d’installation des migrants dans la ville. D’abord nommé le « village corse » de Marseille, cette tradition se poursuit aujourd’hui avec ses habitants d’origine maghrébine, vietnamienne, etc.



from HAL : Dernières publications http://ift.tt/1wEwXil

[medihal-01110996] La Bônoise

La Bône était le nom donné à la ville d’Annaba (Algérie) pendant la période coloniale. Aujourd’hui elle est aussi considérée comme la capitale des harraga (qui signifie « brûleurs » en arabe algérien). Ce terme désigne les « brûleurs de frontières » qui décident de quitter la rive sud de la Méditerranée pour rejoindre illégalement l’Europe.



from HAL : Dernières publications http://ift.tt/1wEwX1V

[hal-01111910] Picard, a solar mission dedicated to the study of the Sun: current results

PICARD is a mission dedicated to the simultaneous measurements of the solar total and spectral irradiances, its diameter and asphericity. It also probes seismically the solar interior by analysing its local intensity variation. PICARD contains a double program with in-space and on-ground measurements. Space observations are a priori most favourable, however, space entails also technical challenges, a harsh environment, and a finite mission lifetime. The PICARD spacecraft, launched on June 15, 2010 will retire in April 2014. On ground, the instruments are less affected by in-space degradation and maintenance is easily provided so if the atmosphere is properly monitored and taken into account, they still represent an opportunity to generate the needed long-term time-series. That is why ground measurements have been carried out since May 2011-and will be pursued after the space program. In this talk, we describe both sets of instruments, and then present our current results. In particular, we show new estimates of the absolute values of the total solar irradiance, diameter and oblateness. We also report about helioseismic studies and about the apparent absence of mid-term trend in the measurement of the diameter.



from HAL : Dernières publications http://ift.tt/1yYY7Bu

[hal-01111910] Picard, a solar mission dedicated to the study of the Sun: current results

PICARD is a mission dedicated to the simultaneous measurements of the solar total and spectral irradiances, its diameter and asphericity. It also probes seismically the solar interior by analysing its local intensity variation. PICARD contains a double program with in-space and on-ground measurements. Space observations are a priori most favourable, however, space entails also technical challenges, a harsh environment, and a finite mission lifetime. The PICARD spacecraft, launched on June 15, 2010 will retire in April 2014. On ground, the instruments are less affected by in-space degradation and maintenance is easily provided so if the atmosphere is properly monitored and taken into account, they still represent an opportunity to generate the needed long-term time-series. That is why ground measurements have been carried out since May 2011-and will be pursued after the space program. In this talk, we describe both sets of instruments, and then present our current results. In particular, we show new estimates of the absolute values of the total solar irradiance, diameter and oblateness. We also report about helioseismic studies and about the apparent absence of mid-term trend in the measurement of the diameter.



from HAL : Dernières publications http://ift.tt/1yYY7Bu

[hal-01111904] Le surendettement en région PACA: quelle réalité? Présentation de l'Observatoire universitaire du surendettement des particuliers.

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from HAL : Dernières publications http://ift.tt/1zp3HSL

[hal-01111904] Le surendettement en région PACA: quelle réalité? Présentation de l'Observatoire universitaire du surendettement des particuliers.

[...]



from HAL : Dernières publications http://ift.tt/1zp3HSL