[hal-01078173] State and Parameter Estimation of Partially Observed Linear Ordinary Differential Equations with Deterministic Optimal Control

Ordinary Differential Equations are a simple but powerful framework for modeling complex systems Parameter estimation from times series can be done by Nonlinear Least Squares or other classical approaches but this can give unsatisfactory results because the inverse problem can be ill-posed even when the differential equation is linear Following recent approaches that use approximate solutions of the ODE model we propose a new method that converts parameter estimation into an optimal control problem our objective is to determine a control and a parameter that are as close as possible to the data We derive then a criterion that makes a balance between discrepancy with data and with the model and we minimize it by using optimization in functions spaces our approach is related to the so-called Deterministic Kalman Filtering but dierent from the usual statistical Kalman ltering We show the root-n consistency and asymptotic normality of the estimators for the parameter and for the states Experiments in a toy model and in a real case shows that our approach is generally more accurate and more reliable than Nonlinear Least Squares and Generalized Smoothing even in misspecied cases



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